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10.1016/j.plaphy.2007.07.017 4 BarrosoJ

Once inside cells and tissues, ALA transforms into dihydrolipoic acid (DHLA), an even stronger antioxidant with the power to neutralize reactive oxygen species while simultaneously chelating transition metals, thereby protecting membrane lipid peroxidation or protein damage [204,205]

395 The loss of double-strand repair pathway due to BRCA1 or BRCA2 mutations renders cancer cells more dependent on the PARPs-mediated repair, and more sensitive to PARP inhibition, raising a possibility of a wider application of PARPi in cancer therapy

For this reason, glutathione plays a fundamental role in maintaining overall cellular health

So it not only is a powerful antioxidant itself but also makes other antioxidants work better

Now, the inflammation can be due to a number of variables and usually is, which means there are many opportunities