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People living with HIV (PLHIV) are particularly susceptible because of a compromised immune system, as the depletion of CD4 + T-cells critically impairs the bodys ability to control Mycobacterium tuberculosis (Mtb) infection, leading to a significantly higher risk of progression from latent to active disease (Getahun et al., 2010)

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4.1 Limitations This study had some limitations

The human samples were collected by Red Cross blood donor service and Aurea biobank according to ethical permits of the biobanks and shared based on research collaboration to this study

Although pathogen reduction methods such as solventdetergent treatment can mitigate some risks, they may also alter or diminish some beneficial plasma components [296]