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The copper ion serves as a cofactor for lysyl oxidase essential for collagen crosslinking and tissue strength

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If your B12 deficiency is due to an autoimmune disease or something that's not related to diet, you may need to get injections every two or three months for the rest of your life

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At the 12 mg dose level, here is what clinical trials reported: Nausea: 43.2% of participants (versus 10.7% on placebo) Diarrhea: 33.1% of participants (versus 13.4% on placebo) Constipation: 25.0% of participants (versus 8.7% on placebo) Vomiting: 20.9% of participants These percentages tell an important story