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(PubMed) Fang H, Kang J, Zhang D

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Age-related changes in renal function, hepatic metabolism, and tissue perfusion theoretically could influence peptide clearance and distribution, though no studies have systematically examined age effects

Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes

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