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Pathogenesis involves crystallization and retention of crystals within the kidneys, which is achieved either through the formation of crystalline plugs in the terminal collecting ducts blocking their openings into the renal pelvis, or formation of plaques of calcium phosphate on the renal papillary surface

This discussion was further clarified in the RY 2005 LTCH PPS final rule (69 FR 25676)

However, HyperHEP B provides immediate protection that allows the vaccine the time needed to establish active immunity in high-risk situations

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