Study design, and diet and treatment groups are diagrammed in Fig
The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)
No special prep is needed
At best they support a plan built on diet, training, steps, and sleep
61:104-108 Masayuki Ikeda, Makoto Asai, Takahiro Moriya, Masami Sagara, Shojiro Inou, Shigenobu Shibata, Methylcobalamin amplifies melatonin-induced circadian phase shifts by facilitation of melatonin synthesis in the rat pineal gland, Brain Research, Volume 795, Issues 12, 8 June 1998, Pages 98-104, ISSN 0006-8993, Carmen Wheatley Cobalamin in inflammation III glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone
Lower starting doses also help distinguish peptide effects from coincidental events
