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To prevent this, formulation steps should be carried out under mild conditionshydrating lipid films at low temperatures, minimizing sonication time, and using aqueous-based dispersion methods whenever possible

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EBioMedicine 85 , 104304 (2022)

This therapy can be beneficial for patients who are unable to obtain sufficient amounts of this nutrient through dietary sources or oral supplements

Scandinavian Journal of Gastroenterology, 2014