b12 injection triggers migraine B vitamins causing migraines? : r/migraine I've had a migraine since

That said, taking your dose at the same time every day matters more than hitting an exact hour

It binds to transport proteins, primarily transcobalamin II , which delivers B12 to tissues throughout the body

[3] [9] Those with neurological symptoms may require more frequent dosing initially (alternate days until improvement) followed by two-monthly maintenance

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Summary: Vitamin B12 supplements can trigger acne in some susceptible individuals, particularly at high doses, by altering skin bacteria behaviour and inflammatory responses