Immunity 53 , 496509 (2020)
AKR1D1 catalyzes the 5-reduction followed by members of the AKR1C enzyme family catalyzing subsequent 3- and 20-reductions
Calmness (00:13:44) Hypothalamic-Pituitary-Adrenal Axis (HPA axis) (00:17:36) The Threat Reflex: Neural Circuits for Fear (00:28:24) Controlling Fear: Top-Down Processing (00:32:27) Narratives: Protective or Dangerous (00:35:58) Attaching Fear to Events: Classical Conditioning & Memory (00:41:45) How Fear Learning Occurs: Long Term Potentiation, NMDA (00:46:10) Extinguishing (Reducing) Fears (00:50:25) Cognitive (Narrative) Therapies for Fear (00:57:56) Repetition of Narrative, Overwriting Bad Experiences with Good (01:05:28) EMDR: Eye Movement Desensitization Reprocessing (01:14:00) Social Connection & Isolation Are Chemically Powerful (01:18:23) Trans-Generational Trauma (01:25:00) PTSD Treatments: Ketamine, MDMA, oxytocin (01:39:25) How Do You Know If You Are Traumatized
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CBD also has the ability to beneficially regulate the oxidative status in microglia by acting as an antioxidant, where it may directly scavenge ROS and/or inhibit the phosphorylation of upstream kinases needed for NF-B signaling in primary microglia cells cultured from mice (van den Berg et al., 2001
14 Intervention protocols vary widely in herbal composition, acupuncture point selection, treatment frequency, and duration, making direct comparisons difficult
