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It appears that the infective organism(s), that cause Lyme, such as the spirochete, Borrelia Burgdorferi, are either huge consumers of vitamin B2, or the inflammatory response the they generate depletes the body of vitamin B2, which in turn inactives vitamin B12, and it is the dual deficiencies that cause the CFS

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Natural Support : Levels can be boosted through sulfur-rich foods, exercise, and adequate sleep

(2014) 23:R18

So it can be tough for a doctor to determine that vitamin B12 deficiency is the problem, unless youve taken a baseline test beforehand and already know that your B12 levels are lower than they should be

The peptide is also detected in saliva and urine