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Specifically, withdrawal from nicotine was shown to induce persistent changes in anxiety-, depression- and compulsive-like behaviors following 7 weeks of electronic cigarette exposure (79, 80), and surprisingly, these behavioral changes persisted 90 days following the last electronic cigarette exposure in male mice (79)

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For example, Public Health England and subsequent UK health authorities have maintained that e-cigarettes are substantially less harmful than smoking, and more recent analyses, including reviews by the Cochrane Collaboration, suggest that e-cigarettes can be more effective than traditional nicotine replacement therapies for helping some smokers quit

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