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Tophi reduce the growth and viability of bone cells (osteoblasts) 24 and if left untreated, tophaceous gout can lead to significant joint erosion and loss of function

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It is not a substrate, inhibitor, or inducer of CYP1A2, CYP2C9, CYP2C19, CYP2D6, or CYP3A4

Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP