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Pan J, Bear C, Farragher S, Cutz E, Yeger H

(2003) revealed that the compound erastin could kill tumor cells via an RAS oncogene mutation, but cell death was not involved in changing the nucleus and caspase-3 activation

Limitations of animal research: Rat healing faster than human, young research animals heal better than aged humans, controlled injury models don't replicate complex human injuries perfectly, dosing conversions uncertain (body weight scaling imperfect), immune system differences affect inflammation and healing