The study results revealed that the direct tumoral administration of the iontophoretic entity causes increased efficacy or therapeutic index due to bypassed systemic exposure of the immunotherapeutic agent as well as drastically changes the toxicity profile of the immunotherapeutic agent [207]
doi:10.1016/s0022-3476(88)80114-8
Specific counseling points: Tell your prescribing physician about every compounded peptide, supplement, and over-the-counter medication you use
Vinoth B, Manivasagaperuma R, Balamurugan S
J Physiol Pathophysiol
This sensitivity arises from the indole ring of Trp, which is characterized by a relatively large dipole moment both in the ground and excited states it extensively interacts with polar and charged groups in its environment, and whose photophysical properties are affected by surrounding residues, solvent exposure, and molecular motion (Lakowicz, 1983