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However, its broad inhibitory activity may cause drug-drug interactions and hepatotoxicity, as ketoconazole can impair the metabolism of other co-administered compounds

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Cochlear development Hair cells in the cochlea possess limited regenerative potential, serving as a promising hearing restoration strategy

The effect of 23 (HA08) was similar to that of brain-derived neurotrophic factor (BDNF) that is a known inducer of spine development ( Small Molecule Insulin-Regulated Aminopeptidase Inhibitors From In Silico Screening In 2008, Siew Chai and her group in Australia disclosed the first generation of drug-like small molecular weight inhibitors of IRAP ( in silico screening of a homology model of IRAP based on the crystal structure of LTA4H (Leukotriene-A4 hydrolase) was applied (Thunnissen et al., 2001)

PMID 25382550