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Future opportunities include hybrid nanoplatforms that integrate redox responsiveness with imaging and enhanced safety, as well as the use of patient-specific GSH/GSSG profiles to guide individualized therapy
doi: 10.1186/s12974-023-02879-7 377 WeinhausB.HomanS.KincaidM.TadwalkarA.GuX.KumarS.et al
It helps regenerate other antioxidants such as glutathione and vitamin E, allowing these systems to continue protecting cells from oxidative stress
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The NETs then activate factors XIIa and XIa of the coagulation cascade, which can cause microthrombi and secondary brain ischemia - and considerably secondary damage
Factors Contributing to Glutathione Depletion: Factors such as chronic stress, poor diet, environmental toxins, and certain medical conditions can deplete glutathione levels, increasing the importance of monitoring and maintaining optimal levels
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