In REDEFINE 1 , a 68-week, Phase 3a, multicenter, double-blind, placebo- and active-controlled trial, 3,417 adults with overweight or obesity but without diabetes were randomized to CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg), semaglutide 2.4 mg, cagrilintide 2.4 mg, or placebo
DOI: 10.1021/ci800058v We recently reported that a physics-informed neural network ("Starling") was capable of rapidly predicting microstate population as a function of pH for diverse organic molecules, and envisioned that we might use Starling's predictions to convert between aqueous solubility and intrinsic solubility
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Expert Opin Drug Metab Toxicol 5:10231038 Nicholson JK, Lindon JC, Holmes E (1999) Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
None of the participants reported: (a) a history of medical or surgical procedures that might have significantly affected the study outcome, including cardiovascular disease or metabolic, renal, hepatic, or musculoskeletal disorders
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