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The KBD area roughly coincides with low-selenium areas including a geological belt extending from northeast to southwest China, North Korea, and eastern Siberia 22

Multiple separate cases of cattle coronaviruses being transmitted to humans have been described [21], and viruses related to feline and canine coronaviruses have been isolated from patients with respiratory symptoms [22, 23]

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Finally, we discuss the effects of glutamine blockade on the tumor microenvironment and explore strategies to maximize the utility of glutamine blockers as a cancer treatment