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Description

Novel GLP-1-based Medications for Type 2 Diabetes and Obesity

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A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

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This same enzyme was subsequently identified by two other laboratories from database searches of proteins containing the conserved G X S X G pentapeptide motif and alpha/beta-hydrolase fold, and was named adipose triglyceride lipase (ATGL) (145) or iPLA2 (53, 145)

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