Feeling tired all the time
This makes people want to move their legs a lot, often with uncomfortable feelings
However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)
Regular intake of these B vitamins, especially in individuals with kidney disease or those who have undergone bariatric surgery, is vital for maintaining a healthy cardiovascular system
Heterogeneity was assessed quantitatively using the I2-statistics and Cochrans Q (Higgins and Thompson, 2002)
Keep in mind that B-complex supplements can contain eight water-soluble vitamins, including: B1 (thiamine) B2 (riboflavin) B3 (niacin) B5 (pantothenic acid) B6 (pyridoxine) B7 (biotin) B9 (folate/folic acid) B12 (cobalamin) Tips For Safe Supplementation 1