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All donors gave written informed consent and protocols were approved by the ethical review board of Fundao Hospitalar de Hematologia e Hemoterapia do Amazonas (CAEE: 51257921.2.0000.0009, approval number #4.982.395/2021)

One solution for the poor specificity is to employ nanoparticle-loaded drugs for delivery to enhance bioavailability, achieve drug accumulation in specific organs or tissues, and reduce toxic side effects

This knowledge can help us find ways to intervene

Minoxidil and finasteride, both approved in the 1980s and 1990s, offer modest and often temporary benefits, require lifelong use, and are associated with tolerability or safety concerns

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They address different systems and are often used together when a patients goals overlap both profiles