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For instance, a study demonstrated that blocking MCU significantly reduced ROS production and mitochondrial swelling in iron-overloaded thalassemic mice, suggesting that MCU could be a therapeutic target for preventing mitochondrial dysfunction in IOC (41, 89)

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Notably, the #14 mutant produced 1.98 g/L of glutathione with a volumetric productivity of 26.36 mg/L/h in the molasses/CSL-based medium, showing efficiency comparable to genetically engineered strains

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The early studies of Golse et al