Ann Emerg Med 1999
Flavonoids as anticancer agents
In murine models, combining the TH-302 nanodrug with PD-1 blockade significantly enhanced antitumor efficacy, leading to greater tumor regression and prolonged survival compared to either treatment alone (306)
In addition to activation by initiator caspases, caspase-3 has been shown to be activated by staurosporine, a non-selective inhibitor of protein kinases (Chae et al., 2000
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