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Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial

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[Abstract]2025 Feb 10;12(5):uhaf043

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Some PK studies report an increased theoretical risk of toxicity with advancing age [62,63,64,65,66,67] due to prolongation of t 1/2 [62, 63], reduced paracetamol clearance [64, 67], increased paracetamol oxidation caused by a reduction in glucuronidation and sulphation capacity [65] or a reduction in liver volume [66]

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