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According to the American Academy of Orthopaedic Surgeons, it may take several weeks to notice an improvement [2]

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GLP-1 receptor agonists like Saxenda (liraglutide, NICE TA664) and Wegovy (semaglutide, NICE TA875) may be considered for patients who meet specific criteria and have not achieved adequate weight loss with other interventions

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Epithalon is a short synthetic tetrapeptide (Ala-Glu-Asp-Gly) with a chemical structure that is being investigated as a potential activator of the telomerase enzyme and stimulant of melatonin release