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To dissect the biochemical derangements imposed by chronic hyperglycaemia, a three-dimensional, tissue-engineered wound model has been engineered that faithfully recapitulates the accumulation of AGEs and the attendant impairment of fibroblast proliferation, angiogenic signaling, and extracellular-matrix turnover that underlie the stalled diabetic repair program (129)

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doi: 10.3390/cells10082075 39 MoonesiMZaka KhosraviSMolaei RamsheSAllahbakhshian FarsaniMSolaliSMohammadiMHet al

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Selection and progression of unimolecular agonists at GCGR, GIPR, and GLP-1R as obesity therapeutics

The therapeutic effect relies on consistent dosing to maintain elevated intracellular GSH concentrations over time