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The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

10.1016/0005-2795(76)90210-5 223 GrosjeanM.LegrandM

These alterations ultimately contribute to heart failure, which is a leading cause of mortality among patients with diabetes ( Figure 1 )

10.2337/diab.23.3.247 208 LegouisD.FaivreA.CippaP

Nonylphenol affects myocardial contractility and L-type Ca 2 + channel currents in a non-monotonic manner via G protein-coupled receptor 30