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Symptoms of B12 deficiency include the following (MHRA, 2022): Neuropathy

The standard formulation is 1:1

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A case report found that taking very high doses of over 5 grams of extended-release niacin can lead to metabolic acidosis, a buildup of acid in body fluids, as well as acute liver failure both of which can be fatal ( Keep in mind that these potentially deadly side effects are associated with taking exceptionally high doses of vitamins