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Adapting proteostasis for disease intervention

May reverse learning deficits in experimental Alzheimers models

Research Background In preclinical research settings, DSIP has been examined across laboratory models, often in the context of: Neuropeptide and hypothalamic signalling studies Sleep-wake cycle and circadian rhythm research models Stress-response and neuroendocrine pathway investigations Published research summaries and references can be accessed via public scientific databases such as PubMed

Mechanistically, this beneficial effect seems to be mediated by the regulation of intracellular Ca 2+ levels by the modulation of calbindin expression, which is associated with calcium homeostasis and plays a role in the protection of dopaminergic neurons in the pathogenesis of PD (Liu et al., 2014)

Anterior Midcingulate Cortex & SuperAgers (01:26:23) Culture, Resilience, Blue Zones & COVID (01:29:18) Adversity, the Positivity Effect & Intergenerational Learning (01:36:31) Sponsor: Lingo (01:38:00) Limitations & Purpose