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Biochimica et Biophysica Acta 1830, 3267-3288

Clinical Significances of Thiamine Deficiency The earliest symptoms of thiamine deficiency include constipation, appetite suppression, and nausea

Vigan P, Parazzini F, Somigliana E, Vercellini P (2004) Endometriosis: epidemiology and aetiological factors

Over time, the brain reduces its own production of these chemicals to compensate, meaning that in the absence of alcohol, dopamine drops and anxiety rises, triggering a craving