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These data support a hypothesis that the T and C allelic variants of the GPX4 gene differ in their capacity to promote selenocysteine incorporation into GPX4, thereby the polymorphism influences an expression and concentration of the enzyme

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Native T4 was first isolated from calf thymus by Allan Goldstein and colleagues in 1981, and its role later expanded far beyond immunology once its actin-regulating function was recognised

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Nat Rev Immunol (2013) 13:15975