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The adaptive immune system functions by first recognizing foreign antigens, and then generating pathogen-specific pathways to eliminate the particular pathogens or cells infected by the pathogen

The vaccine exerts its protective effects by triggering trained immunity via metabolic and epigenetic reprogramming of innate immune cells, without relying on adaptive immune responses induced by protein antigens

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Clinical Relevance: These findings explain GHK-Cu's accelerated wound closure observed in clinical settings and its interest as a therapeutic candidate for chronic wounds, post-surgical recovery, and tissue regeneration applications