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Curr Top Dev Biol 127:49103 Tang TT, Lasky LA (2003) The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism

[Tolerable upper intake level on vitamins and minerals]

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Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats

and cystine, resulting from genetic disorders of amino acid transport (Elsevier BV 2012)

However, regulations differ by region