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The importance of the NRF2 system in Alzheimers disease has been documented by the fact that impairment of NRF2 in mouse models resulted in deteriorated cognitive abilities (Perluigi et al

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Hydroxybenzoic acid, derived from benzoic acid, possesses a C 6 -C 1 carbon structure, while hydroxycinnamic acids, derived from cinnamic acid, typically occur in plants as simple esters with quinic acid or glucose ( Flavonoids are the most well-known and extensively studied class of polyphenols ( Phenolic acids could donate hydrogen atoms, suggesting their antioxidant properties ( On the other hand, flavonoids contribute to activating defense responses by modulating the production of reactive oxygen species (ROS) under stress conditions ( 2.2 Stilbenes This class of polyphenols represents a distinct group of non-flavonoid phytochemicals characterized by two aromatic rings linked by a methylene bridge ( The abundance of resveratrol in red wine has contributed to hypotheses regarding its potential role in preventing chronic diseases (24)

reconstituted refrigerated at 28 C (35.646.4 F) for up to 4 weeks [16]