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They also play a role in disease and are utilized and activated by other ions including calcium, further complicating the relationship between several minerals

Nature 475 , 226230 (2011)

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HIV protease inhibitorsritonavir, indinavir, saquinavir, nelfinavir, and zidovudinewere described as ABCC1 substrate [35], suggesting that the overexpression of ABCC1 in infected cells makes these cells more resistant to chemotherapy

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