In double-blind, placebo-controlled trials, daily application of GHK-Cu cream at 3% concentration for 12 weeks produced a 70% increase in skin collagen thickness as measured by ultrasound imaging, a 40% increase in skin elasticity, and visible reduction in fine lines and wrinkles
Although methylcobalamin and vitamin B12 are terms used interchangeably, vitamin B12 is also available as hydroxocobalamin, a less commonly prescribed drug product (see Hydroxocobalamin monograph), and methylcobalamin
Injectable: tenderness , swelling , bruising at the site, occasional mild flushing or transient fatigue
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However, no peer-reviewed human clinical trials have been published to date
B12 helps regulate your circadian rhythm for optimal sleep-wake cycles