GPX4s activity depends on system xc, a widely distributed amino acid antiporter in the phospholipid bilayer consisting of a light chain subunit (solute carrier family 7A11, SLC7A11 ) and a heavy chain subunit (solute carrier family 3 member 2, SLC3A2 )
For localized injuries, consider perilesional injections in addition to systemic administration
Once captured and neutralized by this antioxidant, these toxins can be safely eliminated through the liver and gut
This work was performed as part of a collaborative effort funded by the WHO/Bill and Melinda Gates Foundation (RG.IMCB.I8-TSA-083) involving the following Institutions and individuals: University of Leeds: D.J
Recent Pat CNS Drug Discov 8: 142160, 2013
Brown GL, Lum RT, Schow SR, Maack C, Vollmer C, Gomez R, Delioukina M, Boulos L, Laxa B, Brown J and Rosen LS