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In vitro studies even show ROS can suppress HNF-4 and lower SHBG, raising free testosterone

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RA-FLS, fibroblast-like synoviocytes from human RA patients

, Kang, M.J

1 Introduction Diabetes mellitus is a metabolic disease characterised by insulin resistance and pancreatic -cell dysfunction leading to disorders in glucose glucose metabolism, which can lead to chronic complications in the body such as cardiovascular disease, nephropathy, retinopathy and others (1)