The time of administration, the time at which the participant reached the 2nd NREM sleep stage, and waking up were recorded, as well as any problems related to the recording
Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists
Ultimately, 76 patients completed the study, but 16 were excluded from the final analysis due to missing or mishandled samples
Equipment Selection Insulin syringes provide the precision needed for micro-dosing
Drop back to the last tolerated dose and stay there for 6-8 weeks before attempting escalation again
Research has documented healing effects on tendons, ligaments, muscles, nerves, blood vessels, and organs including the liver, pancreas, and gastrointestinal tract
