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Its primary mechanisms include promoting angiogenesis (new blood vessel formation) through VEGF upregulation, modulating the nitric oxide system in a context-dependent manner, activating the FAK-paxillin pathway to drive cell migration and tissue rebuilding, and regulating multiple growth factors (PDGF, TGF-beta, FGF) involved in organized tissue repair

Jger R, Kerksick CM, Campbell BI, et al

Meanwhile, ROCK can enhance the transduction of transforming growth factor-1/suppressor of mothers against decapentaplegic homolog signaling [40], thereby inducing endothelial-to-mesenchymal transition, increasing fibrosis markers, and structural remodeling of the microvasculature in the CC [41]

Fully miscible with sterile water and common aqueous buffers used in laboratory preparation and reconstitution

This signaling stimulates collagen synthesis and reduces collagen breakdown

10.1101/cshperspect.a008672 Cold Spring Harb