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Theres really good paper that I quoted in my book about mercury and its effect on the endocrine system

Overexpression of a pepper basic pathogenesis-related protein 1 gene in tobacco plants enhances resistance to heavy metal and pathogen stresses

doi: 10.3390/ijms22179279 74 ZhangYAlexanderPBWangXF

Cambra I, Martinez M, Dder B, GonzlezMelendi P, Gandullo J, Santamara ME, Diaz I (2012) A cathepsin F like peptidase involved in barley grain protein mobilization, HvPap1, is modulated by its own propeptide and by cystatins

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Similarly, poor sleep quality assessed by both questionnaires was related to aspects of COPD severity, such as a higher degree of dyspnea and a worse CAT score