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Indeed, in 23 patients out of a total of 25, 5-MTHF in CSF was low despite normal serum folate treatment with folinic acid for a year restored folate levels and led to clinical improvements

However, a proteasome-independent mechanism might also contribute to CIPN

This is less desirable in a clinical setting as it would necessitate the production of two AAVs, adding significant cost to the development of the therapeutic

Front Immunol 16:1663560 Pelosi AC, Rostirola GC, Pereira JS, Silva KC, Fontanari MER, Oliveira MSP, et al., editors

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Since SASP plays a crucial role in the cellular senescence process, its levels and precise composition can serve as valuable markers of senescence [31]