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Blood 2016 128(22), 2016

In addition to the fact that other biogenic amines can influence how a particular food affects you, there are MANY other variables that determine how you will feel when you eat a high-histamine food: Its impossible to know how much histamine is in a given food, and the same food will contain different amounts of histamine under different circumstances: Some medications interfere with DAO activity, including NSAIDS such as Ibuprofen Estrogen levels stimulate histamine production Stress and physical injury trigger immune cells to release histamine and other pro-inflammatory substances Alcohol interferes with DAO activity Low-histamine trigger foods directly stimulate mast cells to release histamine There is a handful of low-protein, low-histamine plant foods naturally rich in the amino acid histidine (which turns into histamine under the right conditions) Some species of gut bacteria contain histidine decarboxylase and therefore can generate histamine from proteins in the foods we eat

Nat Commun 14 , 4550 (2023)

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