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Despite the promising therapeutic potential of polyphenols like curcumin and resveratrol, their clinical application is often hindered by poor bioavailability, rapid metabolism, and low chemical stability

The ideal treatment depends on the type of pigmentation

Case reports point to a benefit for its use in thyroid storm when combined with methimazole, and an early trial found that a dose of at least 2 g per day could reverse and prevent symptoms of intentionally induced hyperthyroidism among women given a fixed TSH-suppressive dose