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The strong preclinical muscle findings such as IGF-1 overexpression preventing age-related muscle loss in mice used locally expressed native IGF-1 isoforms in animals, not systemically injected IGF-1 LR3 in people

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The control of blood glucose may be driven by the presence of probiotic strains, particularly Lentiactobacillus spp

Overall, the investigators were not blinded to allocation during the experiments and outcome assessment

J Immunol (2016) 197:173342

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