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The compound was also investigated as PL14736 in early-phase IBD clinical work, as described in a 2008 paper by Klicek and colleagues in Journal of Pharmacological Sciences , though that clinical program was never completed or approved

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Antioxidant Signaling and ROS Attenuation Studies in aged rodent models demonstrated that Epitalon treatment reduced markers of oxidative stress, including lipid peroxidation products (MDA) and protein carbonylation, while upregulating superoxide dismutase (SOD) and catalase activity

Maintaining adequate vitamin B12 serum levels may help improve mental health by decreasing the risk of depression and anxiety

However, it is most often produced in the liver, in which the vital substance plays a central role