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Furthermore, a 2024 pharmacological study revealed a startling finding: the TB-500 sequence (Ac-LKKTETQ) itself did not actually increase wound-healing activity in vitro

National Hospital Ambulatory Medical Care Survey: 2019 emergency department summary tables

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The individual evidence for each compound is substantial and replicated in animal research, but the rationale for pairing them is mechanistic: it is based on what each does on its own, not on a study of the combination