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Phase I trials using grape powder containing low-dose resveratrol (equivalent to 80 g/day) revealed selective Wnt pathway inhibition in normal colonic mucosa but not in malignant tissues, suggesting context-dependent efficacy [33]

* No established Nutrient Reference Value

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SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia

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In practical terms, FDA scrutiny centers on safety, manufacturing standards, and whether there is enough reliable human data to justify medical use