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Here are some things to consider: Your Current Health Status If you have a chronic health condition, such as heart disease, diabetes, or kidney disease, discussing this with your healthcare provider is vital

If worsening: Add topical lidocaine for the most affected areas

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By analogy with semaglutide (where the STEP-4 withdrawal trial demonstrated substantial weight regain within 12 months of discontinuation), researchers should anticipate that weight regain is likely following cessation of any GLP-1 class compound, including retatrutide

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