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Nrf2 upregulates the expression of dozens of cytoprotective enzymes, including GCL itself, creating a compensatory response to oxidative stress

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For example, one patient with non-dysplastic Barretts esophagus develops cancer within a year of diagnosis, while another non-dysplastic patient remains cancer-free for decades

Additional lifestyle factors that increase risk include smoking, alcohol consumption, physical inactivity and obesity

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